Principal Scientist, Velocigene- Design & Molecular Biology

Location: Tarrytown
Posted on: June 23, 2025

Job Description:

Regeneron seeks a highly motivated and creative molecular biologist to join our VelociGene team. This is an excellent opportunity for a Principal Scientist to work closely with key research and production groups in order to create best-in-class preclinical models and to innovate on key aspects of our pipeline, with a special focus on long-read sequencing platforms that will enable us to investigate the role of structural variation and genome integrity. As a Principal Scientist, a typical day might include the following: Work with VelociGene and Regeneron colleagues to develop, implement, and innovate on molecular biology techniques, focusing on long-read sequencing platforms. Optimize wet lab molecular biology techniques including high-quality nucleic acid extraction from various tissues and cells, library preparation, and process improvement. Perform robust data quality control and cross-validation. Assist collaborators and the team in designing, implementing, and validating novel algorithms to support various projects including but not limited to DNA structural variation and genome integrity studies. Develop additional expertise in various quantitative and qualitative methods to analyze nucleic acid composition and structure (e.g. microsatellites) as well as single-cell sequencing. Independently create and execute scientifically sound experimental plans using realistic and achievable project timelines and goals. Present results to management and at cross-group meetings. Contribute toward writing protocols and best practices in order to standardize established workflows and to collaborate toward database solutions. Use scientific literature to develop scientific arguments for project justifications, investigation conclusions, new technology, and process improvement ideas. Stay at the leading edge of models development and related technologies by attending relevant conferences and trainings. This role might be for you if: You possess deep knowledge in NGS and long-read sequencing methods development, using genomic DNA from various sources. You are experienced in bioinformatics (particularly scripting in Python and command line); large dataset analyses experience would be a bonus. You are comfortable working in a dynamic, fast-paced, and collaborative environment. You are self-disciplined and proactive in your approach to meeting established projects goals and deadlines. You are detail-oriented, creative, and eager to learn and to implement new ideas and techniques. You have excellent verbal, written, presentation, and interpersonal communication skills. To be considered for a Principal Scientist role, you must have a M.Sc. or a Ph.D. in Molecular Biology, Chemistry, Biochemistry, Cell Biology, or related field, and 5 years of relevant experience (w/Ph.D.) or 8 years of relevant experience (w/M.Sc.) preferably in the biotech industry. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $126,700.00 - $206,900.00

Keywords: , Danbury , Principal Scientist, Velocigene- Design & Molecular Biology, Science, Research & Development , Tarrytown, Connecticut