Senior Scientist- Proteogenomics Approaches for Novel Antigen Discovery

Location: Tarrytown
Posted on: June 23, 2025

Job Description:

We are seeking a highly motivated Senior Scientist who will use our pioneering facilities and technology to perform qualitative and quantitative mass spectrometry experiments focusing on autoimmune, infectious disease, and oncology targets for novel Immunotherapeutics such as bispecific antibodies, cell therapies, and vaccine approaches. You will be to apply the latest mass spectrometry techniques for the discovery and validation of novel disease specific antigens from human tissues and cell lines as well as to develop innovative techniques and investigate innovative technologies to enhance our target discovery efforts. As a Senior Scientist, a typical day might include: Running mass spectrometry-derived data analysis (total proteomics, cell surface proteomics, immunopeptidomics) Carrying out method development and optimization, including automation of current technologies Preparing MS samples from a variety of normal, diseased and tumor samples, including sample pre-fractionation and proteolytic digestion Conducting affinity purification of endogenous proteins/peptides from a variety of samples (i.e., patient tissue biopsies, animal specimens, and cultured cells) Working closely within and across scientific fields to design and perform analyses Presenting data packages and conclusions to internal and external collaborators; preparing results for presentation at conferences and publication This Role Might Be For You If You Have: Strong organizational skills and attention to detail Able to work effectively in a fast-paced industry environment Self-motivated, self-disciplined, and able to function independently, as well as part of a team Strategic agility, strong critical thinking and problem solving Ability to prioritize, multi-task, and work in an evolving environment In order to be considered for this role , you must have at least a Ph.D in biology, biochemistry, biotechnology, or related field with 0-3 years of relevant experience or a BS/MS with 8-10 years. Skill in the operation of an HPLC and mass spectrometer (LC-MS) is required. Experience with various mass spectrometry instrumentation such as Thermo Orbitrap series and Bruker Ultra series is strongly preferred. Knowledge in autoimmunity and immunology desirable. Experience with sample preparation for immunoprecipitation for MS analysis is required. Data analysis of raw MS data analysis using Xcalibur, PEAKS, Spectronaut, FragPipe, Skyline and general DB search engine tools preferred. Prior Immunopeptidomics experience is a plus. Expertise in large-scale data analysis of NGS (Whole Exome sequencing, RNA-seq, RiboSeq and MS proteomics) is a plus. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $108,300.00 - $176,700.00

Keywords: , Danbury , Senior Scientist- Proteogenomics Approaches for Novel Antigen Discovery, Science, Research & Development , Tarrytown, Connecticut