Vice President, Therapeutic Area Lead - CVRM Clinical Development

Location: Tarrytown
Posted on: June 23, 2025

Job Description:

The VP, Cardiovascular Renal Metabolic (CVRM) Therapeutic Area Leader will play an integral role in contributing to and realizing Regenerons vision to become world-leaders in obesity and cardiometabolic disorders management. Reporting to the SVP, CDU Head for Internal Medicine, the VP, CVRM Therapeutic Area Leader will serve as a key member of the Internal Medicine Leadership Team to develop the vision, build and deliver Regenerons growing CVRM portfolio. We envision this portfolio to encompass Obesity and related conditions, Cardiovascular, Renal, and Specialty Medicines, which currently encompass 12 clinical stage assets. The VP, CVRM TAL will also partner with additional related therapeutic areas on areas and assets of intersection Inflammation and Immunology, Neuroscience, Oncology etc. This is a critical strategic and execution role that will develop the strategy and execute the tactics to build Regenerons portfolio and leadership in these interconnected therapeutic areas. To do this, the Therapeutic Area Leader will: Partner with Research and Genetics colleagues to rapidly advance the best therapeutic candidates into the clinical and through clinical development Have direct oversight and accountability for clinical development for all Obesity and CVRM assets from late discovery through lifecycle management, via managing a team of medical directors and clinical scientists (currently ~18 colleagues). Partner with the operations team to ensure high quality execution of the clinical development portfolio Partner with Regulatory team to ensure a streamlined global regulatory strategy and approval of our programs, including establishing innovative end points. Partner with the Medical Affairs and Commercial Colleagues to ensure successful launch of CVRM assets, building a synergistic and robust portfolio. Partner with Research, Genetics, Medical Affairs and HEOR colleagues to build a robust scientific evidence narrative to support and communicate our portfolio. Partner and lead BD processes. This role requires subject-matter expertise in cardiometabolic disorders, experience in clinical development, as well as strong ability to collaborate cross-functionally to build and execute on a shared vision. The successful candidate will have visionary leadership and strong execution with a start-up mindset while leveraging a matrixed environment. Additionally, the successful candidate will have high scientific acumen, strong collaboration and communication skills, proven management and people-development skills, and a record of applying innovation at a global scale. Thought leader who works closely with Global Development, Research, and REGN Senior Management to craft, communicate and drive strategy and execution of those strategies for the CVRM portfolio in alignment with the broader organization needs and vision. Is accountable for overseeing the strategic direction of the portfolio in CVRM in partnership with the Global Program Heads (GPH) that owns the entire life cycle for each asset. Creating asset development strategy, including the clinical development strategy, is led by the GPHs and done in partnership with the clinical leads, as well as the other Strategic Project team representatives. Expected to enhance CVRM capabilities, build and develop talent to grow and lead the organization and ensure continuous improvement, including recruitment of the best external talent, mentoring and talent development, in addition to direct team management. Provides oversight for the teams as they work through key program milestones through Regenerons governance structure; includes Development Program Review (DPR), Protocol review committee (PRC), and Senior management meetings. Attendance is required. Is a change agent and driver capable of adapting to organizational and portfolio growth; works with Internal Medicine Head to identify resourcing and talent development needs for the short and longer term. Effectively recruits, develops and retains a team of clinical and asset leadership experts. Creates a team environment that is consistent with the Regeneron Way. Actively cultivates an environment where people are easily able to be great together through open and active dialogue and idea sharing. This role may be part of Joint Development Committees or senior level interactions with partners. Represents the Companys interests effectively in all interactions with partners, and during due diligence in Business Development interactions. Discovery: Work closely with the TFA (Research) and RGC teams to provide critical clinical/translational input during the target identification/nomination phase across the portfolio of CVRM targets. Together with the TFA heads and RGC, lead the design of studies that will further the human validation of putative targets and/or build insights about human biology for the portfolio, including natural history studies, call-back studies, RWE studies, and non-interventional studies. Ensures appropriate translational data and plans are in place to rapidly advance targets into the clinic, including ensuring development of biomarker plans and appropriate assay readiness to enable earlier decision making and to optimize indication and patient selection. Clinical through Launch: Ensures that the Strategic Project teams (asset teams) develop timely and appropriate clinical plans to rapidly understand translational biology while concurrently driving clinical development plans that support commercialization strategies with maximal patient impact. Supervises the creation of a high-quality clinical plans, serving as the scientific/medical lead for supervising the design of high-quality clinical study protocols, and drive the delivery of informative and actionable results, including close collaboration with the operational team, lead in the interpretation of study results, and ensure the creation of high-quality clinical study reports and memos and make critical recommendations to senior management regarding key decisions and actions. Provides oversight for the clinical design and plan that supports the commercialization of all CVRM assets. This includes close and effective partnerships with Medical Affairs, HEOR, Regulatory Affairs, Global Patient Safety and Global Clinical Operations and with product supply and commercial colleagues. Provides strong operational and lifecycle management oversight for driving critical label enhancing studies, publications and investigator-initiated trials. Partner with Regulatory Affairs to develop innovative regulatory strategies and lead in the development and review of regulatory filings and WMAs. Ensure high quality and compelling advisory committee presentations, supervising presentations and/or stepping up to present as necessary. Lead the organization of clinical advisory boards, steering committees and data safety monitoring boards, as necessary. Drive the development of an optimal publication and plan and delivery of high-quality publications. Develops and maintains relationships with leading external translational scientists and investigators and work closely with Clinical Operations and ROC leadership team to optimize Regenerons external network of key sites in this space. Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business. For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location. Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc. Salary Range (annually) $300,000.00 - $500,000.00

Keywords: , Danbury , Vice President, Therapeutic Area Lead - CVRM Clinical Development, Science, Research & Development , Tarrytown, Connecticut